Histotripsy, a novel noninvasive ultrasound technique, demonstrated effective tumor control in liver cancer treatments.

• 70% of patients treated with curative intent achieved nonviable tumors at 30 and 90 days.
• Complications were rare, with only 1% classified as significant.

Targeting accuracy remains critical; improvements are expected as surgeons gain experience.

• 75% of treatments aimed for complete lesion ablation, but 74% of lesions showed nonviability at day 1, indicating a need for better targeting strategies.