Liposomal bupivacaine provides superior pain relief compared to ropivacaine for patients post-hemorrhoidectomy.

• Patients receiving liposomal bupivacaine had consistently lower resting pain scores (median 0-2.0 vs 2.0-4.0, p<0.001).
• The need for rescue analgesics dropped significantly in the liposomal group (43.9% vs 83.3%, p<0.001).

Consider using liposomal bupivacaine to enhance postoperative comfort and reduce opioid usage.

• Lower defecation pain scores were also reported (median 3.0 vs 5.0, p<0.001).